Knucklebone (disambiguation)

Knucklebone may refer to:
 * Knucklebones, a simplistic game,
 * Knucklebones, a half-elf thief during the time of the Netherese Empire,
 * Knucklebones Gang, a gang of marauders in Avernus,
 * Knucklebone, a female rock gnome wizard,
 * Fort Knucklebone, a location in Avernus.