Twisted Rune

The Twisted Rune is a highly secret cabal of liches and other powerful undead spellcasters. The inner cirlce is highly secretive, and employ agents to do their biding, most are unaware that they work for the Rune. By the Year of the Dracorage, 1018 DR the Rune had become the most powerful organization in southwestern Faerûn, with agents in every country south of the High Moor and west of the Storm Horn Mountains.

The Rune secretly controls nearly half the powerful families of Calimshan, however they rarely act directly to achieve their goals, instead prefering to let time work for them since they are, in effect, immortal.

Halaster's Higharvestide
At dawn on Higharvestide of the Year of the Gauntlet, 1369 DR, two members of the Twisted Rune managed to kidnap Halaster Blackcloak from inside Undermountain. The lich Priamon "Frostrune" Rakesk and the alhoon Ralayan the Ocultacle used a ring of multiple wishes to bind and summon the Mad Mage to Stardock where they intended to probe the great archmages mind for his intricate knowledge of portals and magical gates.

Year of Lightning Storms
In 1374 DR Priamon "Frostrune" Rakesk was fooled by Khelben "The Blackstaff" Arunsun, his former mentor but now hated adversary, into seeking what he thought to be an ancient Shoon artefact. With this artefact he planned to take over control of the Twisted Rune. The Blackstaff struck a deal with Sapphiraktar the Blue, the Rune prefering to have The Blackstaff deal with the traitorous Runemaster rather than having to deal with him themselves. The Frostrune's immobilized body was teleported into the Underhalls, where the Mad Mage, in possesion of the liches phylactery, could take revenge on his former kidnapper.

Shadows of Amn
In Baldur's Gate II: Shadows of Amn the protagonist can uncover a Twisted Rune safe-house in the Bridge District. In this encounter the protagonist can kill Shangalar the Black, a Runemaster of the Twisted Rune.