Artifact

An artifact was a type of magic item of exceptional power that could not be reproduced using normal magical means. Artifacts created through spiritual means were sometimes called relics.

This diverse category included the works of the great civilizations of old, such as Netheril, as well as the many magical creations of deities.

Minor Artifacts
A sampling of minor artifacts of note:
 * Book of Vile Darkness
 * Myrjala's Shards
 * Tablets of Pharyssolnyth
 * Talisman of Shajar
 * Windsong Towerkin ring

Major Artifacts
Major artifacts were usually creations of the gods themselves or at the very least brought into existence through never-before attempted magical exertion or a powerful phenomenon.
 * Chalice of Amaunator
 * Coin of Jisan the Bountiful
 * Ring of Winter
 * Ruby Rod of Asmodeus
 * Shadow Engine
 * Staff of the Forgotten One
 * Stone of Golorr
 * Wyrmskull Throne