As an aggregate in their mortar and adobe, the Azuposi used a silt rich in mica taken from the Dunobo Springs, which was a gateway to the spirit realm of Wenimats. This made the walls of their city of Michaca sparkle in golden hues and imbued them with spiritual power.
Other substances could be added for different outcomes. For example, it was widely known in Faerûn that gorgon, medusa, and even xorn blood mixed in mortar or stucco would block astral or ethereal travel through a wall. To work, this needed a concentration of at least one drop of gorgon blood to each 1 pint (470 milliliters) of water. In comparison, four drops of medusa blood or three drops or xorn blood, together with two drops of unholy water, were needed per 1 pint (470 milliliters) of water; obviously, this was not used in buildings used by good and most neutral faiths. Whatever the formula, no area larger than a man's head should be left uncovered by such mortar.
Reputedly, a solution of two drops of remorhaz ichor and three drops of giant slug spittle added to a flask of amberjet poison and mixed with a mortar would naturally repel all oozes and block them entering a building or going over a wall, without harming them. The formula was kept in Candlekeep and guaranteed to Volothamp Geddarm by a number of merchants, sages, and even Elminster.
Uniquely, the mortar of the Dragonwall guarding Shou Lung was nothing less than the spirit of the great dragon Pao Hu Jen. When the dragon spirit was freed from part of the wall, the mortar between the bricks would vanish and that part of the wall would crumble without its binding force.
Mortars were widely used to hold together simple houses and bridges, and even the biggest structures. However, not all structures used a mortar—buildings in Manass in Khazari used stacks of unmortared stone.
In the Utter East during the Bloodforge Wars (648–657 DR), a thick mortar known as mason mix was used to repair buildings damaged during the fighting and even to restore health to constructed creatures like the stone golems formed from basal golems. 
Aurora's Emporium sold dry mortar used for construction at 5 copper pieces for 1 pound (450 grams). It was said to usable with any stone material or as an exterior coating to wooden frames, and would set in an hour. They also sold a mortar powder for use in spellcasting, at 5 silver pieces for 1 pound (450 grams).
In the Year of the Fifth Circle, 1476 DR, when the entire garrison of paladins at Fort Morninglord disappeared, High Observer Thavius Kreeg of Elturgard ordered it sealed. All entrances were bricked up behind layers of stone and mortar.
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